MCOLN1 and lysosomal storage disease: Loss or mutation of TRPML1 causes the neurodegenerative lysosomal storage disorder mucolipidosis type IV1; vice versa activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection2 and protects human dopaminergic neurons from α-synuclein toxicity through increased lysosomal exocytosis3.