Inflammatory and anti-inflammatory cytokine response was further characterized by the terminal NSG.Tg(Hu-IL-15) mice receiving hu-IL-12 sarcoma cells with significant increases of TNF-α (p = 0.000001) and IL-6 (p = 0.026431) with non-significant elevations in GM-CSF (p = 0.177808) and IL-10 (p = 0.102207) (Supplementary Figure S5f–S5i). The gene discussed is TNF; the disease is sarcoma.