Finally, we examined this IRG signature (ISG15, SIGLEC1, STAT1 RSAD2, IFI27 and IFI44L) in peripheral blood mononuclear cells (PBMCs) collected from a smaller cohort of healthy controls, disease controls, AAV and primary Sjogren’s syndrome (pSS) patients. The gene discussed is SIGLEC1; the disease is peeling skin syndrome.