No significant association of the GRS with any of the obesity-related metabolic variables such as SBP, DBP, TyG, FBG, fasting insulin, HOMA-IR, TC, TG, HDL-C, LDL-C, VLDL-C, CRI, AI, and TG/HDL-C was seen (Table 5). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.