Therefore, the current study has been undertaken to compute the GRS based on five obesity-linked key loci including MC4R rs17782313, BDNF rs6265, FTO rs1421085, TMEM18 rs7561317, and NEGR1 rs2815752 in this at-risk and under-represented population. The gene discussed is NEGR1; the disease is obesity due to melanocortin 4 receptor deficiency.