AIM2 and neoplasm: Additionally, univariate analysis (Table 2) further revealed that tumor size (HR: 3.870; 95% CI 1.764–8.490; P = 0.001), depth of invasion (HR: 5.920; 95% CI 1.410–24.856; P = 0.015), LNM (HR: 0.101; 95% CI 0.024–0.423; P = 0.002), TNM stage (HR: 0.130; 95% CI 0.040–0.429; P = 0.001) and AIM2 expression (HR: 0.135; 95% CI 0.041–0.443; P = 0.001) were all statistically significant prognostic factors.