Additionally, AIM2 expression was further reduced in GC tissues with tumor-node-metastasis (TNM) stage III–IV (P < 0.001) and with tumor size ≥ 5 cm (P < 0.01), compared to TNM stage I–II and tumor size < 5 cm, respectively (Fig. 1d,e). This evidence concerns the gene AIM2 and neoplasm.