Several pathways relevant to migraine were detected: ‘5HT1 type receptor mediated signaling pathway’, ‘metabotropic glutamate receptor group II pathway’, ‘dopamine receptor mediated signaling pathway’, ‘muscarinic acetylcholine receptor 2 and 4 signaling pathway’ and ‘histamine H2 receptor mediated signaling pathway’ were nominally significantly enriched (P < 0.05) among the 181 top eQTLs (Pbeta < 0.01). The gene discussed is HRH2; the disease is migraine disorder.