The observed apoptotic and necrotic cells in the hippocampal tissue samples obtained from rat models of epilepsy (Fig. S4B) can be caused by a reduced expression level of UCH-L1 and a significant increase in expression levels of apoptosomal microtubular network organizers (transgelin-3, cofilin-1, profiling-1 and GAP43) triggering a biochemical cascade that leads to the acute neuronal death. Here, TAGLN3 is linked to epilepsy.