Recently a new ANA-ELISA was introduced by Phadia company for connective tissue disease screen that includes 17 different antigens (dsDNA, SSA/Ro (52+ 60), SSB/La, U1-RNP (RNP-70, A, C), Sm, centromere B, Jo-1, Scl-70, Rib-P, fibrillarin, RNA Pol III, PM-Scl, PCNA and Mi-2)9. This evidence concerns the gene SSB and connective tissue disorder.