BOP1 and non-small cell lung carcinoma: Compared with Sod1+/+ KP NSCLC cells, 12S pre-rRNA was strongly depleted, while its precursor 32S pre-RNA showed a moderate reduction in Sod1−/− KP NSCLC cells (Fig. 5g), mimicking pre-rRNA processing defects observed upon inhibition of PeBoW function through knockdowns and dominant-negative mutants of BOP1 and PES135,36.