At least five out of 12 types of cancer examined including breast invasive carcinoma (BRCA), kidney renal papillary cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), lung squamous cell carcinoma (LUSC) and LUAD show significant down-regulation of FCN3 in tumor tissues (Supplementary Fig. 1A). The gene discussed is FCN3; the disease is invasive breast carcinoma.