We performed IHC assay to detect the autophagy marker LC3 and p62 in liver tumor and tumor-free liver tissue of WT, NLP+/− and NLP−/− mice, found that in NLP+/− and NLP−/− mice, LC3 was downregulated while p62 was upregulated, in both tumor and liver. Here, MAP1LC3A is linked to neoplasm.