DEFA1 and viral infectious disease: Critical proteins in viral infection and inflammatory response, include host defense peptides like DEFA1, apoliproteins (APOs), and interferon-stimulated genes like SAA1 as uncharacterized antiviral gene,31 accurate phase proteins like complement C6, and the corresponding lipids or amino acids also play functions in the regulation, such as PCs, TGs, PS, and amino acids, as shown in Supplementary Fig. 9b.