In the attempt to explore the potential of BH3 mimetics as anti-MPM therapy, we investigated genetic status, transcriptional expression, and dependency profile of the pro-survival BCL-2 gene family (BCL2L1, BCL2L10, BCL2, BCL2A1, BCL2L2, and MCL1) in MPM by interrogating TCGA dataset and functional genomics that determines genetic dependencies in cancers (DepMap; https://depmap.org/portal/). The gene discussed is MCL1; the disease is cancer.