BCL2 and neoplasm: Overexpression of pro-survival B-cell lymphoma 2 (BCL-2) family members (BCL-2, BCL-XL, MCL-1, BCL-W,BCL-B, and BFL-1) is a key apoptosis evasion mechanism that promotes tumor growth by keeping pro-apoptosis effectors (BAX/BAK) in check11.