By using a previously defined “primed for apoptosis” gene signature, determined by transcriptional expression of the pro-apoptotic genes (BAK1, BAX, BBC3, BID, BIK, BOK, and HRK)37, we curated the “primed for apoptosis” score of H2452, MSTO-211H, H28, and H2052 cells, chosen for the availability of their transcriptomic data in the Catalog of Somatic Mutations in Cancer (COSMIC). This evidence concerns the gene BBC3 and cancer.