Taken together, our in vivo studies provided experimental evidence that TNFR1 drives severe skin inflammation in mice with keratinocyte-specific IKK/NF-κB inhibition by inducing RIPK1-mediated necroptosis and apoptosis, suggesting that RIPK1-dependent cell death could also contribute to human inflammatory skin diseases. The gene discussed is TNFRSF1A; the disease is inflammatory skin disease.