MCL1 and acute myeloid leukemia: Although other mechanisms, such as the alterations in the fatty acid metabolism [36], mitochondrial oxidative phosphorylation [37], and electron transport chain complexes [38], may be involved in the synergistic interaction, Mcl-1 inhibition was evident to be importantly associated with the synergistic cell death in AML cells induced with venetoclax and ATO combination in this study.