KDR and hepatocellular carcinoma: Findings from Zhuang group, obtained by using human specimens from hepatocellular carcinoma patients and mouse xenograft models, demonstrated that peritumoral hypoxia was negatively correlated with peritumoral neuropilin1 and VEGF receptor-2 (VEGFR-2) expression, and with tumoral/peritumoral microvascular density.