In support of its role as a tumor suppressor gene, Sema3F was found downregulated in highly metastatic human melanoma cell lines in vitro and in vivo, and cells overexpressing Sema3F showed a reduced cell adhesion and migration toward fibronectin and were chemorepulsive for vascular and lymphatic endothelial cells expressing neuropilin2, thus indicating the effect of Sema3F on stromal cells, other than melanoma cells [45]. This evidence concerns the gene SEMA3F and neoplasm.