On the contrary, two years later, in agreement with data obtained with mammary adenocarcinoma [89], Casazza et al. reported a positive correlation between Sema3E and melanoma progression, being all the Clark levels III and IV metastatic melanoma specimens positive for the expression of Sema3E, while benign skin lesions showing only a low percentage of positivity. The gene discussed is SEMA3E; the disease is breast adenocarcinoma.