In particular, while melanoma cell proliferation was not affected by Sema3F in results obtained by Bielenberg group [45], negative effect on cell proliferation was demonstrated by Chabbert-de Ponnat et al. either with the addition of exogenous soluble Sema3F, or after induced overexpression of the recombinant molecule [93]. The gene discussed is SEMA3F; the disease is melanoma.