The group of Jian H demonstrated the role of Sema4B in suppressing the growth and the metastatization of non-small cell lung cancer [48, 49], shedding light on the ability of hypoxia to regulate invasion of lung carcinoma through transcriptional repression of Sema4B mediated by the binding of HIF-1α to HRE present in Sema4B gene. The gene discussed is SEMA4B; the disease is lung carcinoma.