Similarly, the ability of Sema4D to induce tumor growth and vascularization through a HIF-1-dependent mechanism was demonstrated, together with a correlation between the expression of Sema4D and the activity of HIF-1 in specimens from head and neck squamous carcinoma [53, 54] and from epithelial ovarian cancer [59]. The gene discussed is SEMA4D; the disease is neoplasm.