At protein level, several semaphorins, plexins and neuropilins have been detected in tissue cancer available in the database, including melanoma, except for Sema4A, Sema4F, Sema4G, Sema6B, plexinA4, plexinB3 for which melanoma specimens resulted weakly positive or prevalently negative. This evidence concerns the gene SEMA4A and melanoma.