Using a cutoff of 50 ng Hb/ml buffer, FIT sensitivity for CRC detection was higher than any of the described single markers or marker panels alone; sensitivity 81.4% [95%-CI 69.8–93.0%] at a specificity of 98.0%, AUC 0.946 (Fig. 3c, d). The gene discussed is GSTM1; the disease is colorectal carcinoma.