Linear regression analyses using The Cancer Genome Atlas (TCGA) CRC dataset indicated that Sec62 mRNA level is positively correlated with the CSC markers/regulators including CD44, CD133, EPCAM, ITGB1 and BMI1 (Additional file: Figure S1A), indicating that Sec62 might regulate the stemness of CRC. The gene discussed is CD44; the disease is colorectal carcinoma.