In a phase I/II clinical study with 30 stage IV RCC patients, intradermal administration of naked mRNA encoding mucin 1 (MUC1), CEA, human epidermal growth factor receptor-2 (HER-2)/neu, telomerase, survivin and MAGE-A1 combined with GM-CSF was well tolerated and associated with stable disease in 15 patients and one partial response [90]. Here, ERBB2 is linked to renal cell carcinoma.