One example is a human papilloma virus (HPV)16 E6 and E7 mRNA-encoding RNA-LPX vaccine, which is being evaluated in a randomized phase II trial in combination with pembrolizumab in patients with HPV16+ and PD-L1+ head and neck squamous cell carcinoma (HNSCC) (NCT04534205). This evidence concerns the gene CD274 and head and neck squamous cell carcinoma.