Adoptive transfer of DCs transfected ex vivo with mRNA encoding an agonistic anti-GITR mAb delayed tumor growth in mice in the absence of an antigen-specific immunization, with efficacy being comparable to that of intravenous delivery of high amounts (1 mg) of recombinant anti-GITR mAb [180]. Here, TNFRSF18 is linked to neoplasm.