The PI3K/AKT pathway has critical roles in regulation of cell proliferation and tumor progression. PI3K activates AKT that regulates various effectors such as CREB, p27, FOXO, and mTOR. Tyrosine kinase receptors and phosphatase and tensin homolog (PTEN) are known as the positive and negative regulators of the PI3K/AKT pathway, respectively. This evidence concerns the gene PTEN and neoplasm.