Since miR-665 mimics modulated human LUSC cell proliferation, cell cycle and apoptosis, TRIM8 was affirmed as a direct target of miR-665, thus, TRIM8 was silenced in NCI-H226/SK-MES-1 cells by siRNA to confirm its involvement in the pro-tumor roles of miR-665. This evidence concerns the gene TRIM8 and neoplasm.