Interleukin 6 is one of the most prominent cross-taking cytokine involved between inflammation and T2DM [44] whereas, IL-10 which is an anti-inflammatory cytokine plays an important role in the regulation of immune response, leading to decreased cytokine production, lower tissue factor expression, inhibiting matrix-degrading metalloproteinase, and promoting the phenotype switching of lymphocytes to the Th2 cell [45, 46]. This evidence concerns the gene IL6 and type 2 diabetes mellitus.