Slug, Snail, E-cadherin, N-cadherin, and β-catenin, which are involved in epithelial-mesenchymal transition (EMT), have also been reported to promote cancer cell migration and invasion [17, 18, 38–43], while RhoA, Cdc42, and Rac1 are members of the Rho family of small GTPases, and are key mediators of actin polymerization and cell migration. This evidence concerns the gene CDH2 and cancer.