Evaluation of the expression of genes throughout the spectrum of liver injury in Mdr2 −/− mice (n = 4 per group) showed a significant increase in intrahepatic inflammatory responses during inflammation and cirrhosis time points, which was followed by immunosuppression with the development of HCC (Supporting Fig. 6, Additional File 1). The gene discussed is ABCB4; the disease is hepatocellular carcinoma.