TRIM25 and hepatocellular carcinoma: The results showed that the mean expression levels of TRIM25 in HCC tissues were 1.2 times than that in adjacent tissues (P < 0.05) (Fig. 4a), and the expression levels of TRIM25 in HepG2.2.15 cells were also significantly higher than that in HepG2 cells (P < 0.05) (Fig. 4b), indicating that TRIM25 was highly expressed in HCC tissues and cells.