MAPT and Alzheimer disease: Moreover, women with an apolipoprotein E ε4 allele (+APOE4 genotype) exhibit greater AD pathology than men, particularly in relation to tau pathology (Buckley et al., 2019, Hohman et al., 2018, Ramanan et al., 2019), demonstrating that this genetic risk factor confers greater AD risk in women, compared to men (Altmann et al., 2014, Breitner et al., 1999, Bretsky et al., 1999, Farrer et al., 1997, Mortensen and Hogh, 2001, Payami et al., 1996).