IL4R and helminthiasis: Studies addressing eosinophil expansion and responses in allergic airway inflammation (Cohn et al., 1999; Nieuwenhuizen et al., 2012), respiratory viral infection (Castilow et al., 2008; Johnson et al., 2003), and helminth infection (Mearns et al., 2008; Spencer et al., 2001) all show noticeably reduced eosinophil responses in Il4ra−/− mice.