ANKRD26 and Thrombocytopenia: We study a multigenerational family impacted by congenital thrombocytopenia, resembling inherited thrombocytopenia 2 (THC2; Online Mendelian Inheritance in Man accession no. 188000; Noris et al., 2011; Pippucci et al., 2011; Tan et al., 2020; Turro et al., 2020), which is typically caused by single nucleotide variants (SNVs) that de-repress ANKRD26 expression during megakaryocytic differentiation (Bluteau et al., 2014; Marconi et al., 2017).