Interestingly, in addition to the well-characterized importance of IL-6 and BAFF in sustaining B cell-mediated immunity [27,52–54], only recently type I IFN has been demonstrated by a systems biology approach to be predictive of an immune response in humans vaccinated with yellow fever vaccine YF-17D [55] or with seasonal influenza vaccine [56]. Here, TNFSF13B is linked to influenza.