The lowered plasma fibrinolytic activity, mainly ascribable to the elevated plasma antigen and activity levels of PAI-1, has been associated with the development of cardiovascular diseases and recurrent myocardial infarction according to a study in 2018 which concluded that good glycemic control during T2DM management is very essential to reduce the risk of cardiovascular disease onset [15]. Here, SERPINE1 is linked to cardiovascular disorder.