SERPINE1 and myocardial infarction: The lowered plasma fibrinolytic activity, mainly ascribable to the elevated plasma antigen and activity levels of PAI-1, has been associated with the development of cardiovascular diseases and recurrent myocardial infarction according to a study in 2018 which concluded that good glycemic control during T2DM management is very essential to reduce the risk of cardiovascular disease onset [15].