SERPINE1 and type 2 diabetes mellitus: The up-regulation of the PAI-1 during the inflammatory event induced by the T2DM may also be influenced by the various polymorphisms associated with the PAI-1 gene as was confirmed by the study which observed much stronger elevation in PAI-1 in the acute-phase after acute-trauma for patients with the 4G-allele than for those with the 5G-allele [24].