Previous studies have also shown that hypoxia-reoxygenation (H-R) may increase intracellular ROS levels to activate the MAPK/ERK pathway and that the CLIC1 protein participates in the migration of LOVO colon cancer cells by regulating the ROS/ERK pathway during H-R [69]. The gene discussed is CLIC1; the disease is malignant colon neoplasm.