GLIPR1 and neoplasm: In two experiments using our doxycycline-dependent GliPR1 knockdown system, whereby mice underwent subcutaneous and cranial transplantation of a shGliPR1-transduced clone (clone 980-5 transduced with GliPR1 sh#301), those mice treated with doxycycline to induce GliPR1 knockdown had reduced subcutaneous tumor volume and cerebral tumor area compared to those left untreated.