GLIPR1 and central nervous system cancer: This evidence of prolonged survival associated with GliPR1 knockdown in glioma cells is supported by another study in nude mice using xenografts derived from glioma stem cells (GSCs): mice cranially transplanted with xenografts of GSCs transduced with an shGliPR1 had significantly prolonged survival compared to a control group cranially transplanted with xenografts of GSCs transduced with a control shRNA (P < 0.001) [24].