HLA-DRB1 and rheumatoid arthritis: RA genetic research has identified over 100 RA-related gene loci, such as HLA, PTPN22, and TRAF1-C5, and determined that the main RA susceptibility gene in China is HLA-DRB1 [22], PADI4 in Japan [23], PTPN22 in northern European [24], and ACE I/D allele in Arab [25].