Genes associated with neural pathways and neurological disorders and immune-related functions presented significant weaning-by-MIA interaction effect, including OTX2, cholinergic receptor nicotinic alpha 2 subunit (CHRNA2), acid phosphatase 7, immunoglobulin heavy variable 3-23 (VHZ), and a gene annotated to the ribosome pathway PIGY upstream reading frame (PYURF) (Tables 1 through 3 with Tables 1 and 2). The gene discussed is OTX2; the disease is nervous system disorder.