F10 and deep vein thrombosis: Other studies have reported similar adverse effects.8,15,19,20 A single-center, retrospective cohort study of 4F-PCC used for either reversal of fXa inhibitor induced life-threatening bleeding or need for emergent procedure also found only one adverse effect, a DVT.14 A large, multicenter study found thrombotic events in 3.8% of patients.8 Thus, according to this study and previous literature, it appears that 4F-PCC is a relatively safe intervention in the treatment of fXa inhibitor- and warfarin-related bleeding.