To generate a broad cross section of RASopathy models, we stably expressed inducible transgenes for 13 RASopathy-associated human gene isoforms in flies: six PTPN11 disease isoforms (Y279C, R498T, E510Q, D61G, N308D, E510P), three RAF1 disease isoforms (S257L, L613V, D486G), two BRAF isoforms (T531, Q257R), and single isoforms of KRAS (G12D) and HRAS (G12S). The gene discussed is KRAS; the disease is RASopathy.