TIMP1 and Dupuytren Contracture: This study confirmed significant upregulation of MMP‐2 (P < .001) and identified several additional genes that were significantly upregulated in Dupuytren disease nodule tissue, including MMP‐1 (P < .001), MMP‐13 (P < .001) and MMP‐14 (P < .001); 3 members of the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motif) family, particularly ADAMTS‐14 (P < .001); and tissue inhibitor of matrix metalloproteinase 1 (TIMP‐1, P < .001).43