SFRP4 and Dupuytren Contracture: The authors hypothesized, from functional studies in primary myofibroblasts derived from surgically resected Dupuytren disease tissue, that decreased secretion of Sfrp4 may increase Wnt3a signalling via the noncanonical pathway, and the authors concluded that changes in WNT signalling play a role in the fibrotic phenotype (Table 3).32, 34, 60