Currently, the European Society of Cardiology (ESC) and EASD guidelines have endorsed GLP-1 analogs and sodium glucose transporter 2 (SGLT2) inhibitors as the first-line therapies, rather than metformin, for patients with diabetes having atherosclerotic cardiovascular disease (ASCVD) or a high risk of cardiovascular events [9]. Here, GLP1R is linked to diabetes mellitus.