Excessive oxidative stress and consequent eNOS uncoupling have been demonstrated in mouse models (Xia et al., 2010; Herranz et al., 2012; Varadharaj et al., 2012; Yin et al., 2017) and patients with atherosclerosis (Varadharaj et al., 2012; Ismaeel et al., 2018) as well as in animal models (Adlam et al., 2007; Toral et al., 2018; Cheng et al., 2020; Dong et al., 2020) and patients with hypertension (Cengiz et al., 2015). Here, NOS3 is linked to hypertensive disorder.