LAMP2 and Danon disease: Further highlighting the role of the autophagy-lysosomal system in cardiovascular homeostasis, deficiency in the lysosome-associated membrane protein 2 (LAMP2) (one of the main lysosomal membrane glycoproteins) causes Danon disease, a pathology characterized by massive autophagosome deposition in cardiomyocytes (Platt et al., 2018; Zhu et al., 2020).