PLAC4 and neoplasm: Zeng et al. (2020) found that LINC01116, overexpressed in LUAD, promoted tumor proliferation and metastasis. Xiao et al. (2019) revealed that FAM83A-AS1 accelerated tumor migration and invasion by targeting miR-150-5p and modifying MMP14 in LUAD. PLAC4, located in 21q22.2, is documented highly expressed in the placenta, and SNPs in the transcriptional regions are associated with fetal trisomy 21 (Lo et al., 2007).