NUCB1 and pancreatic neoplasm: We used two pancreatic cancer cell lines, SW1990 and CFPAC1, which relatively express lower levels of NUCB1 compared to HPDE, a normal pancreatic duct epithelial cell line (Supplementary Figure 2A), to generate stable cells with overexpression of NUCB1 or control vector (Supplementary Figures 2A,B).