Besides, in the hypertrophic heart induced by ISO, the expression of SIRT6 was down-regulated, while the inhibition of mTOR restored cardiac function in muscle-specific SIRT6 knockout mice, which spontaneously developed into cardiac hypertrophy (Saxton and Sabatini, 2017; Ravi et al., 2019). This evidence concerns the gene MTOR and cardiac hypertrophy.