In addition, studies have found that SIRT6 also promotes the production and secretion of inflammatory cytokines (Van Gool et al., 2009; Bauer et al., 2012; Jiang et al., 2013, 2016), leading to chronic inflammation, which is the basis of neuronal death in Parkinson’s disease and other neurodegenerative diseases (Nicholatos et al., 2018). The gene discussed is SIRT6; the disease is neurodegenerative disease.