BRAF and melanoma: Moreover, image analysis and machine learning were also applied to quantify tumor infiltrating lymphocytes (TILs) on HE, revealing to be a better tool than the actual semiquantitative classification in brisk, non-brisk and absent to estimate survival for melanoma patients (46, 50, 51) and to be associated with response to checkpoint inhibitors in BRAF V600E/K mutated malignant melanomas (50)