Similarly, the method was used to show a specific expression profile in fibrotic areas with high macrophage and T cell infiltration in BAP-1 negative uveal melanoma, suggestive of T-cell exhaustion other than PD-1/CTLA-4 engagement, as well as mechanisms of immune exclusion, supporting the clinical observation of immunotherapeutic failure in this subgroup and the need for development of specific treatment approaches (48). This evidence concerns the gene BAP1 and uveal melanoma.