The histopathological analysis of the tumor morphology revealed that DCA and DCA/Rano induced focal regions of necrosis and hemorrhage with increased Ki67 proliferation indices and DNA fragmentation (cell death; TUNEL staining) in Gl261 tumors (Figure 9B); Rano significantly decreased Ki67 in Gl261 tumors but increased TUNEL in CT2A tumors. The gene discussed is MKI67; the disease is neoplasm.