Adenosine monophosphate-activated protein kinase is considered neither an ally nor an adversary in the progression of cancer (143), and the upregulation of PI3K/Akt pathway with concomitant inhibition of PTEN in most cancers leads to LKB1 impairment in the activation of AMPK for its tumor suppression role (144). Here, AKT1 is linked to neoplasm.