Koka et al. [23], after age, smoking history, performance status, and treatment adjusting of GBM patients, revealed that HER2 overexpression significantly raised the early mortality odds (the median survival of patients for HER2 overexpression was four months compared to eight months for lack of overexpression), which were confirmed by Potti et al. [38] Therefore, the results showed that overexpression of HER2 may be a weak prognostic marker in GBM cases [23] and astrocytic tumors of the brain [36]. This evidence concerns the gene ERBB2 and glioblastoma.