Meanwhile, improved tumor hypoxia promotes the infiltration of effector T cells to the tumor since T cells tend to avoid hypoxic areas and head to neighboring normoxic regions in TME.[72] Photosynthesis‐boosted immunogenic PDT shows a great ability to ameliorate the TIME by elevating the percentage of immune effector cells such as CD8+ T cells, CD4+ T cells, and NK cells, and decreasing the number of immunosuppressive cells such as Tregs, MDSCs, and M2‐like tumor‐associated macrophages (TAM) which are important for suppressing anti‐tumor immunity.[73]. Here, CD4 is linked to neoplasm.