CPE and neoplasm: Due to the high expression of specific antigens on the surface of tumor cells, bacterial toxins that specifically target these antigens, such as Diphtheria toxin (DT) and Clostridium perfringens enterotoxin (CPE), and Pseudomonas exotoxin (PE) can be used for targeting and killing cancer cells.[96] Among them, DT has been widely used in tumor treatment both in mice and humans because of its relatively desiable anti‐tumor effect.[97] This may benefit from its strong cytotoxicity or the simultaneously induced anti‐tumor immunity.