Based on this novel strategy, authors further armed attenuated S. typhimurium with the ability to synthesize IL‐18, which is an IFN‐γ‐inducing factor with multiple functions related to the proliferation and activation of immune cells.[63] In preclinical mouse cancer models, the endowment of IL‐18‐producing ability greatly increased S. typhimurium’s anti‐tumor activity. Here, IL18 is linked to cancer.