In TME, tumor‐associated M2‐like macrophages promote tumor growth by inhibiting DCs maturation, down‐regulating the expression of major histocompatibility complex (MHC) molecules, and recruiting regulatory T cells.[56] Interestingly, it has been proved that flagellin can reverse the tumor immunosuppressive microenvironment into immune‐responsive TIME by the polarization of M2‐like macrophages to M1‐type macrophages. Here, HLA-C is linked to neoplasm.