MMP8 and neoplasm: Studies have reported that matrix metalloproteinase 8 (MMP‐8) played a vital role in this release process.[30] Moreover, the early expansion of Clostridium in solid tumors could lead to intratumoral infiltration of granulocytes and macrophages, and the increased secretion of chemokines would further trigger the adaptive immunity and recruit immune cells (e.g., CD8+ T cells) to the tumor site.[25a]