The transcription factor hepatocyte nuclear factor 4 alpha (HNF4α) is highly expressed in the liver, and its downregulation is required for HCC development.[15, 16] Herein, we identified a new oncogenic lncRNA that was upregulated in HCC and named it lnc‐APUE (lncRNA accelerating proliferation by upregulating E2F1). This evidence concerns the gene E2F1 and hepatocellular carcinoma.