Taken together, downregulation of HNF4α may lead to the upregulation of lnc‐APUE, and lnc‐APUE may work as a miR‐20b sponge to prevent the miR‐20b‐mediated repression on E2F1 expression, thereby promoting G1/S transition and tumor growth (Figure 8F). Here, E2F1 is linked to neoplasm.