In tumor cells, HNF4α downregulation leads to lnc‐APUE upregulation, which may work as a miR‐20b sponge to prevent the miR‐20b‐mediated repression on E2F1 expression, resulting in increase of E2F1 level and in turn acceleration of G1/S transition and tumor growth. Here, E2F1 is linked to neoplasm.