Rs72487966 (SNP on chromosome 16) is located in the WW domain containing oxidoreductase (WWOX) gene region, which is a risk gene for T2D.[10] As shown in Figure 2F, allele G of rs72487966 is related to an increased leucine/isoleucine level (p = 2.92 × 10−6, β = 0.411, MAF = 0.03). The gene discussed is WWOX; the disease is type 2 diabetes mellitus.